Although as Hanna explains, "so-and-so fatigue" can be used slangily in lots of different situations to mean that you're bored with "so-and-so."

For example, "I love computer games but I think I'm developing FPS and MORPG * fatigue. I miss the old LucasArts adventure games like Monkey Island!"

And in the context of HIV epidemiology, the phrase condom fatigue has been used to describe the problem that "people have stopped practicing 'safer sex' because they dislike wearing condoms."

Note that condom fatigue does NOT mean that the condoms themselves have become weak and ineffective because of chemical changes in the latex rubber -- although metal fatigue, in the context of engineering and architecture, means that the metal itself has lost its strength.

* FPS = The "first-person shooter" genre of computer games, like Doom and Duke Nukem; MORPG = "multiplayer online role-playing game", like World of Warcraft.