I was always told that if I have an animate noun after a verb like знать I use genitive
For instance,
Я знаю этого человека.
However, I found that having negation in the sentence can turn it to accusative
Ты не знаешь его жену?
But can I still say
Ты не знаешь его жены?
If I can use both...then my questions are:
Is there a big difference? What would you say?