For a woman, they are very much two different candidates. One supports the reversal of Roe v. Wade and one does not.
For a GLBTG, they are very much two different candidates. One supports Marriage Equality and one does not.
The other issues like taxes and spending and cutting out FEMA and all that... we have heard promises/threats all before like "read my lips" and they were never kept. However, over the past few years our country has made great strides to be much more inclusive. Much more understanding of others and it would be a very sad day if we started to go backwards. To single out a class of people and say you are not worthy of being married because you are not "normal." Or to tell a young woman what she can or can't do with her own body (for whatever reason) because it is YOUR religious belief and not hers.