1) = при таких обстоятельствах (under such circumstances)
Doctor to patient: "I'm so sorry to report that you are terminally ill. There's no medicine to help you. Тут уж ничем не поможешь — he said, shrugging.

2) = теперь (now that)
Wife: darling, couldn't you move the couch, I want to wipe the floor under it.
Husband: sure I could (he has moved the couch). Can I help you with something else?
Wife: No, thanks, тут уж я сама справлюсь.