I guess everyone is aware that Paul McCartney is a left-handed musician. Actually it does not ring any bells when a person uses his left and right hands in a mirrored fashion but to be a mirrored musician one need to have a mirrored instrument. Paul McCartney turned his guitar from left to right and reverted strings from top to bottom. In this way the most thin string which is at the bottom for a right-handed guitarist turned to be at the bottom for left-handed Paul McCartney also.
Today I've seen a street band with a left-handed accordeonist and his accordeon WAS NOT mirrored it was just turned over from left to right. In this way the actions of the left-handed accordeonist are not the mirrored versions of a right-handed one. He utilize his own unique technique for playing an acordeon.