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I've heard it mostly used towards males but have heard it towards females. To me it sounds weird directed towards a female.
Dude can kind of be a replacement for a few words like (man, guy):
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So, do you use the word for sarcasm and irony only?[/quote]
That's a very good question! You have me thinking now. I guess I would also use it as a character trait, to describe someone, "He is a...