Ты is a singular you
Вы is a plural you or a POLITE singular you, not used in colloquial convesation like that, only to mean plural you
Что is pronounced as што not что.
The most similar English sound to Russian "Ш" is English "Sh". They're not completely the same though. English "SH" sounds more like "ШЬ" than "Ш". If you want to make a good Russian "Ш" I'd suggest you try to pronounce the sustained "R" sound and remember the tongue position for that. Then you do the same but pronounce "SH" with that "R-tongue position" and lips should move the same way you move them for the "SH"
Also, in coloquial conversation Что as an object is pronounced like "ЧЁ (CHYO)". You can't pronounce "ЧТО" as "ЧЁ" if "ЧТО" is a conjuction. In this case it would be "ШТО"